Morris Faiman's research focuses on substance abuse. Specifically, he studies the mechanism of action of agents used in the treatment of alcohol abuse. His research focuses on the specific drug disulfiram and its bioactive metabolites. Faiman also studies on the mechanism(s) by which alcohol can become addictive. In this work, the various disulfiram metabolites are used as pharmacological tools to investigate the role of various brain neurotransmitters to provide a better understanding of substance abuse addiction and how it develops.